Anti-Depressant Agent KNT-127 Reduces Stress as Well as Depression

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Article via https://www.tus.ac.jp

Scientists have developed a potential anti-depressant that exhibits anti-stressing as well as anti-depressant effects with minimal side effects.
This anti-depressant agent exhibits the dual nature of being a stress reliever and an anti-depressant and could broaden the potential of existing treatments.
They observed that prolonged administration of KNT-127 during (anti-stress effect) and after stress (anti-depressant effect) period, significantly improved social interaction and levels of serum corticosterone (a hormone secreted under stress in mice) in cVSDS mice.
In contrast, when administered after stress, KNT-127 did not affect newborn neuron survival rate at all.
However, further research is warranted for better insights regarding DOP agonists and the mechanism underlying their anti-depressant effects.

Please check out the complete article (source in English): https://www.tus.ac.jp/en/mediarelations/archive/20230501_1431.html
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