Recurrent Brain Trauma May Increase Alzheimer’s Risk

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Research over the last several decades suggests that there might be a relationship between repetitive or severe traumatic brain injury (TBI) and abnormal amyloid-beta accumulation.
“Amyloid-beta accumulation in the brain is proposed to be an early event in the pathogenesis of Alzheimer’s disease, the most common type of dementia worldwide, impacting millions of people.”
Abnormal amyloid accumulation was seen in six of the nine participants who were exposed to explosions.
Three of the participants had one region of the brain with increased amyloid accumulation, two participants had two regions, and one participant had three regions with abnormal accumulation.
None of the healthy control participants showed any abnormal amyloid accumulation.

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